Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Sinclair Method is a revolutionary approach to treating Alcohol Use Disorder. Instead of requiring people to stop drinking immediately, it uses a medication — Naltrexone — to help gradually reduce alcohol cravings and dependency. Individuals take Naltrexone one hour before drinking, which blocks the opioid receptors in the brain and, over time, extinguishes the reward response to alcohol.
For those who have developed a dependence on alcohol, quitting abruptly might seem like the best decision. However, sudden alcohol cessation can be dangerous—especially for individuals who consume large amounts regularly. The body becomes physically reliant on alcohol, and stopping all at once can trigger severe withdrawal symptoms.
For anyone aiming to monitor or reduce their alcohol intake, understanding the concept of alcohol units is a vital first step. In the UK, alcohol units provide a clear measure of the pure alcohol content in drinks, making it easier to gauge how much you’re consuming. A UK alcohol units calculator simplifies this process, ensuring accuracy and convenience. Let’s explore how these calculators work, their importance in fostering healthier drinking habits, and how they can fit into your lifestyle.
Through TSM, gradual reduction provides a controlled framework that helps minimise relapses, making it a viable and often more sustainable choice.